What is the 1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE?

1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE is , while it's Molecular Formula is C10H12N2O4. a-Stavudine is an epimer of Stavudine (S685250), an antiviral used to prevent and treat HIV/AIDS.

What is the CAS number for 1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE?

The CAS number of 1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE is 84414-90-4.

What is the 1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE?

1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE is , while it's Molecular Formula is C10H12N2O4. α-Stavudine is an epimer of Stavudine (S685250), an antiviral used to prevent and treat HIV/AIDS.

What is the CAS number for 1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE?

The CAS number of 1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE is 84414-90-4.

Cost-effective and customizable 1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE 84414-90-4 supplier

Q: What is 1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE (84414-90-4) used for?

1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE, also known as a-Stavudine, is a chemical compound that is an epimer of Stavudine (S685250). It is a nucleoside analog with a unique structure, featuring a 2,3-dideoxy-A-D-glycero-pent-2-enofuranosyl moiety attached to a thymidine base. 1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE has antiviral properties and is used in the prevention and treatment of HIV/AIDS.

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1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE

CAS No.: 84414-90-4
Purity: 99%

Cost-effective and customizable 1-(2,3-DIDEOXY-A-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE 84414-90-4 supplier

Molecular Formula: C10H12N2O4
Molecular Weight: 224.216
PSA： 84.32000
Density: 1.374±0.06 g/cm3 (20 ºC 760 Torr)
LogP: -0.70910

84414-90-4 Relevant articles

Facile synthesis of 2',3'-unsaturated nucleosides from 2-deoxyribose

Sujino, Keiko,Yoshida, Tomoyasu,Sugimura, Hideyuki

, p. 6133 - 6136 (2007/10/03)

A straightforward approach for the synth...

Synthesis of antiviral nucleosides from crotonaldehyde. Part 3. Total synthesis of didehydrodideoxythymidine (d4T)

Jung,Gardiner

, p. 3841 - 3844 (2007/10/02)

The total synthesis of the antiviral age...

New synthesis of 2',3'-didehydro-2',3'-dideoxynucleosides.

Abdel-Megied,Hansen,Pedersen,Nielsen

, p. 1060 - 1063 (2007/10/02)

The 3'-iodonucleoside 4 and the 3'-O-met...

Synthesis of 2'-azido, 2,2'-anhydro and 2',5'-anhydro nucleosides with potential anti-HIV activity

Abdel-Megied,Pedersen,Nielsen

, p. 313 - 317 (2007/10/02)

Reaction of methyl 2-bromo-2,3-dideoxy-5...

84414-90-4 Process route

: 5-Methyl-1-((S)-5-trityloxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione

: 84414-90-4
1-(2,3-dideoxy-α-D-glycero-pent-2-enofuranosyl)thymine

: 3056-17-5
stavudin

Conditions

Conditions	Yield
With Dowex ^R 50W; hydrogen cation; In methanol; Yield given. Yields of byproduct given;

: 132747-40-1
(2R,3R)-3-(2,2-Dimethoxyethyl)oxiranemethanol

: 3056-17-5,26638-87-9,84414-90-4,133008-05-6,135212-56-5
1-(2,3-dideoxy-D-glycero-pent-2-enofuranosyl)thymine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 11 percent / Et₂AlF / CH₂Cl₂ 2: 97 percent / pyridine 3: 50 percent / t-butyldimethylsilyl triflate / CH₂Cl₂ 4: 95 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 2 h / -5 - 25 °C 5: NH₃ / methanol With pyridine; ammonia; diethylaluminum fluoride; 3-chloro-benzenecarboperoxoic acid; t-butyldimethylsiyl triflate; In methanol; dichloromethane;
Multi-step reaction with 6 steps 1: 30 percent / Et₂AlF / CH₂Cl₂ 2: 95 percent / 1.5percent HCl in MeOH / CH₂Cl₂ 3: 97 percent / pyridine 4: 50 percent / t-butyldimethylsilyl triflate / CH₂Cl₂ 5: 95 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 2 h / -5 - 25 °C 6: NH₃ / methanol With pyridine; hydrogenchloride; ammonia; diethylaluminum fluoride; 3-chloro-benzenecarboperoxoic acid; t-butyldimethylsiyl triflate; In methanol; dichloromethane;

Yield

Multi-step reaction with 5 steps

1: 11 percent / Et₂AlF / CH₂Cl₂

2: 97 percent / pyridine

3: 50 percent / t-butyldimethylsilyl triflate / CH₂Cl₂

4: 95 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 2 h / -5 - 25 °C

5: NH₃ / methanol

With pyridine; ammonia; diethylaluminum fluoride; 3-chloro-benzenecarboperoxoic acid; t-butyldimethylsiyl triflate; In methanol; dichloromethane;

Multi-step reaction with 6 steps

1: 30 percent / Et₂AlF / CH₂Cl₂

2: 95 percent / 1.5percent HCl in MeOH / CH₂Cl₂

3: 97 percent / pyridine

4: 50 percent / t-butyldimethylsilyl triflate / CH₂Cl₂

5: 95 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 2 h / -5 - 25 °C

6: NH₃ / methanol

With pyridine; hydrogenchloride; ammonia; diethylaluminum fluoride; 3-chloro-benzenecarboperoxoic acid; t-butyldimethylsiyl triflate; In methanol; dichloromethane;

84414-90-4 Upstream products

139212-87-6
1-(5-O-tert-butyldiphenylsilyl-2,3-dideoxy-3-iodo-D-threo-pentafuranosyl)thymine
139212-94-5
1-(5-O-tert-butyldiphenylsilyl-2-deoxy-3-O-methylsulfonyl-α,β-D-erythro-pentofuranosyl)thymine
77421-68-2
S'-acetyl-d4T
132747-40-1
(2R,3R)-3-(2,2-Dimethoxyethyl)oxiranemethanol