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Factory Sells Best Quality 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone 204205-33-4 with stock
- Molecular Formula: C11H10BrFO
- Molecular Weight: 257.102
- Vapor Pressure: 0.002mmHg at 25°C
- Refractive Index: 1.592
- Boiling Point: 293.012 °C at 760 mmHg
- Flash Point: 131.009 °C
- PSA： 17.07000
- Density: 1.574 g/cm3
- LogP: 3.24080
2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone(Cas 204205-33-4) Usage
InChI:InChI=1/C11H10BrFO/c12-10(11(14)7-5-6-7)8-3-1-2-4-9(8)13/h1-4,7,10H,5-6H2
204205-33-4 Relevant articles
2 - Bromo 2 - (2 - fluorophenyl) ethanone preparation of cyclopropyl (by machine translation)
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Paragraph 0040; 0044; 0047; 0048; 0052; 0056, (2018/04/26)
The invention belongs to the technical f...
PROCESS FOR THE PREPARATION OF HIGH-PURITY PRASUGREL
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Page/Page column 13, (2018/04/11)
The field of invention relates to a nove...
An anti-platelet drug prasugrel method for the preparation of (by machine translation)
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Paragraph 0033; 0034; 0035, (2016/12/16)
The invention discloses an anti-platelet...
Method for preparing antithrombotic drug prasugrel intermediate
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Paragraph 0025; 0062-0064, (2017/04/03)
The invention discloses a method for pre...
204205-33-4 Process route
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150322-73-9
1-cyclopropyl-2-(2-fluorophenyl)ethanone
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204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions
| Conditions | Yield |
|---|---|
|
With
iodine(I) bromide; 1-n-butyl-3-methylimidazolim bromide;
In
tetrahydrofuran;
at 40 ℃;
for 4h;
Temperature;
Time;
Concentration;
|
95.3%
|
|
With
bromine;
In
methanol;
at 25 - 30 ℃;
for 6h;
Concentration;
|
94.65%
|
|
With
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2'-azobis(isobutyronitrile);
In
cyclohexane;
at 10 ℃;
Product distribution / selectivity;
Reflux;
|
93.28%
|
|
With
bromine;
In
tetrahydrofuran;
at 20 ℃;
for 10h;
|
90.4%
|
|
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile);
In
chloroform;
at 20 ℃;
for 8h;
Temperature;
Solvent;
Reagent/catalyst;
|
83.2%
|
|
With
N-Bromosuccinimide; toluene-4-sulfonic acid;
at 80 ℃;
Product distribution / selectivity;
|
78%
|
|
With
hydrogen bromide; dihydrogen peroxide;
In
ethanol; water;
for 0.5h;
Product distribution / selectivity;
Heating / reflux;
|
73.8%
|
|
With
hydrogen bromide; dihydrogen peroxide;
benzyltriethylammonium bromide;
In
water;
at 85 ℃;
for 2h;
Product distribution / selectivity;
|
67.1%
|
|
With
N-Bromosuccinimide; dibenzoyl peroxide;
In
tetrachloromethane; toluene;
|
|
|
With
N-Bromosuccinimide; dibenzoyl peroxide;
In
tetrachloromethane;
for 6h;
Heating / reflux;
|
|
|
With
N-Bromosuccinimide; dibenzoyl peroxide;
In
chloroform;
for 6h;
Heating / reflux;
|
|
|
With
hydrogen bromide; dihydrogen peroxide;
In
1,4-dioxane; water;
at 20 - 85 ℃;
for 2 - 120h;
Product distribution / selectivity;
|
|
|
With
N-Bromosuccinimide;
In
dichloromethane;
for 10h;
Product distribution / selectivity;
Heating / reflux;
|
|
|
With
N-Bromosuccinimide;
In
tetrachloromethane;
Product distribution / selectivity;
|
|
|
With
pyridine; bromine;
In
dichloromethane;
at 20 ℃;
for 12h;
Product distribution / selectivity;
|
|
|
With
bromine;
In
dichloromethane;
at 20 ℃;
for 12h;
Product distribution / selectivity;
|
|
|
With
bromine;
In
acetic acid;
Product distribution / selectivity;
|
|
|
With
hydrogen bromide; dihydrogen peroxide;
In
water; acetic acid;
at 95 ℃;
for 1h;
Product distribution / selectivity;
|
|
|
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); toluene-4-sulfonic acid;
In
tetrachloromethane;
at 75 ℃;
for 3h;
|
|
|
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); toluene-4-sulfonic acid;
In
chloroform;
for 4h;
Reflux;
|
|
|
With
hydrogen bromide; dihydrogen peroxide;
In
water;
at 25 - 40 ℃;
|
|
|
With
N-Bromosuccinimide; dibenzoyl peroxide;
In
ethyl acetate;
at 25 - 60 ℃;
Product distribution / selectivity;
|
|
|
With
N-Bromosuccinimide;
dibenzoyl peroxide;
In
1,2-dichloro-ethane;
for 7h;
Reflux;
|
|
|
With
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2'-azobis(isobutyronitrile); acetic acid;
at 60 - 85 ℃;
for 2.41667h;
|
|
|
With
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic acid;
2,2'-azobis(isobutyronitrile);
at 60 - 85 ℃;
for 2.41667h;
|
|
|
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile);
toluene-4-sulfonic acid;
In
chloroform;
at 0 - 5 ℃;
for 4.75h;
Reflux;
|
|
|
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile);
toluene-4-sulfonic acid;
In
dichloromethane;
at 0 - 5 ℃;
for 4.75h;
Reflux;
|
|
|
With
N-Bromosuccinimide; toluene-4-sulfonic acid;
In
acetonitrile;
at 40 ℃;
for 24h;
|
|
|
With
bromine;
In
methanol;
Large scale;
|
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4606-07-9
ethyl cyclopropylcarboxylate
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204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
Conditions
| Conditions | Yield |
|---|---|
|
With
iodine; magnesium; isopropyl bromide;
In
tetrahydrofuran;
at 65 ℃;
for 3h;
ethyl cyclopropylcarboxylate;
In
tetrahydrofuran;
at 5 - 70 ℃;
for 3.16667h;
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); toluene-4-sulfonic acid;
In
chloroform;
at 28 - 65 ℃;
for 4h;
|
204205-33-4 Upstream products
-
150322-73-9
1-cyclopropyl-2-(2-fluorophenyl)ethanone
-
451-82-1
(2-fluorophenyl)acetic acid
-
946402-23-9
2-(2-fluorophenyl)-N-methoxy-N-methylacetamide
-
345-35-7
2-fluorobenzyl chloride
204205-33-4 Downstream products
-
150322-38-6
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
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