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Buy Good Quality STAUROSPORINE 62996-74-1 with a minimum purity of 99%
- Molecular Formula: C28H26N4O3
- Molecular Weight: 466.539
- Appearance/Colour: off-white powder
- Vapor Pressure: 3.25E-18mmHg at 25°C
- Melting Point: 270 °C
- Boiling Point: 677.523 °C at 760 mmHg
- PKA: 14.25±0.70(Predicted)
- Flash Point: 363.553 °C
- PSA： 69.45000
- Density: 1.562 g/cm3
- LogP: 5.07370
STAUROSPORINE(Cas 62996-74-1) Usage
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Biological Activity |
Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset? . |
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General Description |
A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint. |
InChI:InChI=1/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/p+1/t17-,20-,26-,28+/m1/s1
62996-74-1 Relevant articles
PROCESS FOR THE PURIFICATION OF INDOLE CARBAZOLE ALKALOIDS
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Page/Page column 16, (2021/09/11)
Disclosed is a process for the purificat...
COMPOUNDS FOR IMMUNOPOTENTIATION
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Page/Page column 140, (2010/02/15)
Methods of stimulating an immune respons...
Design and implementation of an efficient synthetic approach to pyranosylated indolocarbazoles: Total synthesis of (+)-RK286c, (+)-MLR-52, (+)-staurosporine, and (-)-TAN-1030a
Wood, John L.,Stoltz, Brian M.,Goodman, Steven N.,Onwueme, Kenolisa
, p. 9652 - 9661 (2007/10/03)
A total synthesis of the natural product...
Total synthesis of (+)-RK-286c, (+)-MLR-52, (+)-staurosporine, and (+)-K252a
Wood, John L.,Stoltz, Brian M.,Goodman, Steven N.
, p. 10656 - 10657 (2007/10/03)
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62996-74-1 Process route
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195617-12-0
C37 H34 N4 O6
-
-
62996-74-1
staurosporine
Conditions
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
3
steps
1: 79 mg / H2
/ PtO2
/ aq. acetic acid
2: 2.) BH3
*DMS / 1) THF; 2) THF, toluene, reflux, 2 h
3: 70 percent / TFA, anisole / 48 h
With
dimethylsulfide borane complex; hydrogen; methoxybenzene; trifluoroacetic acid;
platinum(IV) oxide;
In
acetic acid;
|
|
|
Multi-step reaction
with
3
steps
1: 96 percent / H2
/ PtO2
2: BH3
*Me2
S
3: CF3
CO2
H, anisole
With
dimethylsulfide borane complex; hydrogen; methoxybenzene; trifluoroacetic acid;
platinum(IV) oxide;
|
-
-
188028-33-3
C37 H36 N4 O5
-
-
62996-74-1
staurosporine
Conditions
| Conditions | Yield |
|---|---|
|
With
methoxybenzene; trifluoroacetic acid;
for 48h;
|
70%
|
|
With
methoxybenzene; trifluoroacetic acid;
Yield given;
|
62996-74-1 Upstream products
-
174291-07-7
ent-7-oxostaurosporine
-
125035-83-8
7-carbonyl staurosporin
-
188028-33-3
C37 H36 N4 O5
-
188028-11-7
C36 H34 N4 O5
62996-74-1 Downstream products
-
129623-30-9
(5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14(5h)-one
-
125035-83-8
7-oxoylidenestaurosporine
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