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Atomoxetine hydrochloride

  • CAS No.: 82248-59-7
  • Purity: 99%
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What is the Atomoxetine hydrochloride ?

Atomoxetine hydrochloride is solid, while it's Molecular Formula is C17H22ClNO. (R)-Tomoxetine hydrochloride has been used as a noradrenaline reuptake inhibitor:to study the role of L-threo-3,4-dihydroxyphenylserine (L-DOPS) in the pathogenesis of Alzheimer′s disease in miceto study its effects on set shifting in ratsto study its effects on rat brain as a result of its long-term use

What is the CAS number for Atomoxetine hydrochloride ?

The CAS number of Atomoxetine hydrochloride is 82248-59-7.

More information of Atomoxetine hydrochloride 82248-59-7 are:

Synonyms

Benzenepropanamine,N-methyl-g-(2-methylphenoxy)-,hydrochloride, (R)-;Benzenepropanamine, N-methyl-g-(2-methylphenoxy)-, hydrochloride, (gR)- (9CI);(R)-(-)-N-Methyl-3-[(2-methylphenyl)oxy]-3-phenyl-1-aminopropane hydrochloride;(R)-(-)-Tomoxetine hydrochloride;(R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropylamine hydrochloride;(R)-Tomoxetine hydrochloride;Atomoxetine hydrochloride;LY 139603;Strattera;Tomoxetine hydrochloride;(3R)-N-Methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine hydrochloride (1:1);(3R)-N-méthyl-3-(2-méthylphénoxy)-3-phénylpropan-1-amine chlorhydrate;benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (gammaR)-, hydrochloride;Atomoxetine HCL;

CAS?Number

82248-59-7

Molecular Formula

C17H22ClNO

Molecular Weight

291.821

Melting Point

167-169oC

Boiling Point

389 °C at 760 mmHg

Flash Point

164.1 °C

HS CODE

29221990

PSA

21.26000

LogP

4.91750

Pka

10.13(at 25℃)

What is Atomoxetine hydrochloride (82248-59-7) used for?

Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki values of 5, 77, and 1,451 nM for norepinephrine, serotonin, and dopamine transporters, respectively. It is selective over the choline, GABA, and adenosine transporters, and a number of neurotransmitter receptors, ion channels, second messengers, and brain/gut peptides. In the rat prefrontal cortex (PFC), it increases extracellular norepinephrine and dopamine by 3-fold and increases Fos expression. Atomoxetine (0.1, 0.5, and 1 mg/kg) reduces premature responding, a measure of impulsivity, by rats in the 5-choice serial reaction time test (5CSRTT) in a dose-dependent manner. It also has neuroprotective effects when administered prior to ischemic damage in a gerbil model of transient cerebral ischemia. Formulations containing atomoxetine have been used in the treatment of attention-deficit hyperactivity disorder (ADHD) in children, adolescents, and adults.

InChI:InChI=1/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H

Articles related to Atomoxetine hydrochloride:

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R-(-)-atomoxetine hydrochloride preparation method

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Paragraph 0087; 0091-0093; 0097-0099; 0103-0104; 0109, (2019/09/14)

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