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(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine
- CAS No.: 1269662-73-8
- Purity: 99%
Quality products?make an important contribution to long-term revenue and profitability. (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine GMP Manufacturer Global Trade 1269662-73-8 with Fast Delivery
1.What is the (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine ?
Pyrotinib, is a potent and selective EGFR/HER2 dual inhibitor.
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![diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate](/upload/2026/6/d324e16f6073418ab02665c7bf9de15f_f6837ed8-b402-4168-bce7-a2f44121efe1.png)
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1269662-79-4
diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate
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852324-28-8
(2R)-1-methylpyrrolidine-2-formaldehyde
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![(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine](/upload/2026/6/60ccccae43134baa941e381d1587551d_6ba76901-c4a6-4cad-861e-2c0b6375de03.png)
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1269662-73-8,1246089-97-3
(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine
Conditions
| Conditions | Yield |
|---|---|
|
diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
for 0.5h;
Cooling with dry ice;
(2R)-1-methylpyrrolidine-2-formaldehyde;
In
tetrahydrofuran; toluene;
at 20 ℃;
for 12.5h;
Cooling with dry ice;
|
19.7%
|
|
diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
for 0.5h;
Cooling;
(2R)-1-methylpyrrolidine-2-formaldehyde;
In
tetrahydrofuran; toluene;
at 30 ℃;
for 12.5h;
Cooling;
|
19.7%
|
|
diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
for 0.5h;
Inert atmosphere;
Cooling;
(2R)-1-methylpyrrolidine-2-formaldehyde;
In
tetrahydrofuran;
at 20 - 30 ℃;
for 12.5h;
Inert atmosphere;
|
19.7%
|
|
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
at 20 ℃;
for 13h;
|
19.7%
|
|
diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
for 0.5h;
Cooling with ice;
Inert atmosphere;
(2R)-1-methylpyrrolidine-2-formaldehyde;
In
tetrahydrofuran; toluene;
at 20 - 30 ℃;
for 12.5h;
Inert atmosphere;
|
46 mg
|
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![[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]boronic acid](/upload/2026/6/84f5a73866494db9836aed644a1e1b43_c5204c89-daa7-4854-8c21-c51d8bca7931.png)
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[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]boronic acid
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![(2E)-N-(4-amino-3-cyano-7-ethoxyquinolin-6-yl)-3-[(2R)-1-methylpyrrolidine-2-yl]acrylamide](/upload/2026/6/bcc09aa727304087ac33d38f0fe60957_843d88dd-ba59-46c7-98f8-65f18529b188.png)
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(2E)-N-(4-amino-3-cyano-7-ethoxyquinolin-6-yl)-3-[(2R)-1-methylpyrrolidine-2-yl]acrylamide
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1269662-73-8,1246089-97-3
(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine
Conditions
| Conditions | Yield |
|---|---|
|
With
dmap; copper(l) chloride;
In
toluene;
at 40 ℃;
Reagent/catalyst;
Solvent;
Temperature;
|
91%
|
2.What is the CAS number for (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine ?
The CAS number of (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine is 1269662-73-8.
More information of (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine 1269662-73-8 are:
|
CAS?Number |
1269662-73-8 |
3.What are another words for (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine ?
Synonyms?for?(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine 1269662-73-8:(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine
4.What is the molecular formula of (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine?
The chemical formula of ?(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine is?C32 H31 ClN6 O3 which containing 32 Carbon atoms,31 Hydrogen atoms,1 Chlorine atoms,6 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of??(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine?is 583.09.
5.What is (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine (1269662-73-8) used for?
Relevant articles related to (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine:
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Article |
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Preparation method of pyrrotinib |
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METHOD FOR PREPARING TYROSINE KINASE INHIBITOR AND DERIVATIVE THEREOF |
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6.Buy (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine with the best price .
Nanjing distinctions Medical Technology Co., Ltd. is a quality supplier of (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine 1269662-73-8.
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